Recent studies using an EEG frequency tagging approach have reported modulations of alpha, beta and theta bands at the stimulation frequency during nociceptive/painful thermal stimulation compared to non-nociceptive/non-painful vibrotactile stimulation. Prior expectations of the intensity of upcoming painful stimuli are known to strongly modulate the subjective experience of those stimuli. Thus, modulating the expectation of pain should result in a change in the modulation of oscillations if these factors are indeed linked.

 

In this study, Leu, Glineur and Liberati modulated expectations of pain (low or high intensity) in 40 participants prior to delivering thermal cutaneous stimulation (low, medium or high intensity). They recorded how intense participants expected the pain to be, and how intense they felt it to be, as well as EEG to assess oscillatory differences across the expectation and intensity conditions.

 

The results confirmed that there was a strong effect of expectation on the perceived stimulus intensity. However, contrary to the hypotheses, this was not reflected in the cortical oscillations. Overall this indicates a possible dissociation between perceived pain and modulation of ongoing oscillations in the theta, alpha and beta bands. 

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.

 

URL to the preregistered Stage 1 protocol: https://osf.io/y6fb8
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
 
List of eligible PCI RR-friendly journals:

 

• Advances in Cognitive Psychology
• F1000Research
• Brain and Neuroscience Advances
• Cortex
• Imaging Neuroscience
• In&Vertebrates
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Psychology of Consciousness: Theory, Research and Practice
• Studia Psychologica
• Royal Society Open Science
   

References
 
1. Leu, C., Glineur, E. & Liberati, G. (2023). Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? [Stage 2] Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/awrge